Edición de «Blood-Brain Barrier-Penetrating Metal-Organic Framework Antioxidant Nanozymes For Targeted Ischemic Stroke Therapy»

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Through the receptor-mediated transcellular pathway, the transferrin-coated MOF nanoparticles achieved environment friendly transport across the BBB and focused accumulation at the cerebral ischemic damage site of mice with center cerebral artery occlusion/reperfusion (MCAO/R), whereby the nanocarrier exhibited catalytic activities of ROS decomposition into O2 and H2O2-responsive rapamycin release. By its BBB-concentrating on, antioxidative,  [http://47.103.92.60:3003/viviandunlap20/bloodvitals-tracker1987/wiki/Are+Normal+Oxygen+Levels%253F BloodVitals SPO2] anti-inflammatory, and  [https://humanlove.stream/wiki/User:ReganGoss15 BloodVitals SPO2] antiapoptotic properties, the MOF nanosystem addressed multiple pathological elements of IS and realized exceptional neuroprotective results, resulting in the substantial reduction of cerebral infarction quantity and accelerated restoration of nerve features in the MCAO/R mouse mannequin. 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