US20060264716A1 - Microneedle With Glucose Sensor And Methods Thereof - Google Patents

Microneedle know-how supplies a useful minimally-invasive technique to sample blood. Attributable to their small measurement, microneedles can pierce pores and BloodVitals SPO2 skin and BloodVitals SPO2 take minute portions of blood with minimal influence and or BloodVitals SPO2 ache to the topic. In spite of their benefits, prior artwork microneedle techniques are still somewhat invasive since they involve the extraction of blood from the affected person. Implanted in vivo sensors present another means to pattern blood chemistry that does not require blood extraction. It would be desirable to attain a less invasive method that wouldn't extract blood from the affected person and supply longer measurement occasions than in prior art in vivo units. This invention relates to a microneedle with a glucose sensor. FIG. 3A is a perspective of an array of microneedles with glucose sensors in accordance with embodiments of the current invention. FIG. 4B is a facet, cross-sectional view of a working microneedle. FIG. 4C is a facet view of one other array of microneedles in accordance with embodiments of the current invention.



10 area of at least one of many needles which remains exposed to the conductive substrate and on a minimum of a portion of the conductive layer. 200 uM tall, 40 uM in diameter at the tip, and far wider at the bottom. In some embodiments, the wants aren't any wider at the base than the tip or they are only considerably wider. Microneedles of this measurement have been shown to supply entry to interstitial body fluid without reaching the capillaries or nerves, so there is no discomfort. This conductive layer is to cowl the needle and its instant base, however not the tip or BloodVitals SPO2 the encompassing space, so that each needle has an impartial electrical connection. These may very well be materials like glucose oxidase for the detection of glucose level in interstitial fluids followed by a protecting layer to block out common interferences. FIG. 1 shows an isometric view and FIG. 2 exhibits a piece view to show the bodily building and layers.



FIGS. 3A-3B and FIGS. 4A-4C Rows of needles are proven related together in FIGS. 3A-3B and FIGS. 4A-4C , however they is also individually sensed and BloodVitals SPO2 inserted. Nafion or PTFE is utilized to block common interferences. This results within the array of needles as proven in FIGS. This background worth can be used a baseline from which to measure the analyte of curiosity using the working needles. Having a reference worth and working values, permits a more sensitive measurement, because the reference value might be subtracted from or divided into the working value to successfully remove physique fluid and environmental variations. Therefore, monitor oxygen saturation the spirit and scope of the appended claims shouldn't be restricted to the outline of the preferred versions contained herein. CROSS REFERENCE TO Related Applications - This application claims the good thing about U.S. Provisional Application No. 60/674,465 filed Apr. 25, 2005, your entire disclosure of which is incorporated herein by reference. Government SPONSORSHIP - This invention was made with government assist under Grant NAG3-2744 awarded by NASA.



The federal government has certain rights within the invention. BACKGROUND - Microneedle know-how supplies a useful minimally-invasive technique to pattern blood. Due to their small measurement, microneedles can pierce pores and BloodVitals SPO2 skin and take minute portions of blood with minimal influence and BloodVitals SPO2 or ache to the subject. Despite their benefits, prior artwork microneedle techniques are still somewhat invasive since they contain the extraction of blood from the patient. Implanted in vivo sensors provide another means to sample blood chemistry that doesn't require blood extraction. Unfortunately, in vivo sensors work together with the physiology and BloodVitals SPO2 are vulnerable to degradation throughout use. It could be desirable to achieve a much less invasive method that would not extract blood from the patient and supply longer measurement instances than in prior art in vivo devices. Field OF THE INVENTION - This invention relates to a microneedle with a glucose sensor. FIG. 4C is a side view of one other array of microneedles in accordance with embodiments of the present invention.